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Article

Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia.

Breast cancer research and treatment - 1 Nov 2008

Smart Chanel E, Clarke Catherine, Brooks Kelly M, Raghavendra Ashwini, Brewster Brooke L, French Juliet D, Hetherington Rehan, Fleming Jean S, Rothnagel Joseph A, Wainwright Brandon, Lakhani Sunil R, Brown Melissa A

Abstract excerpt

Tumours arising in BRCA1 mutation carriers have a characteristic phenotype, the molecular and cellular basis of which is unknown. To address the hypothesis that this phenotype reflects a role for BRCA1 in either in the basal or the stem cell compartments of the mammary epithelia, we have targeted...

Read the complete abstract on PubMed

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Share to BRCA1 Protein
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Gene Expression Regulation, Neoplastic

Share to Genes, BRCA1

Share to Mammary Glands, Animal

Share to Stem Cells

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Source

Identifiers

PMID: 18095153
DOI: 10.1007/s10549-007-9859-2

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18095153-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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