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Article

Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity.

RNA (New York, N.Y.) - 1 Feb 2008

Chen Po Yu, Weinmann Lasse, Gaidatzis Dimos, Pei Yi, Zavolan Mihaela, Tuschl Thomas, Meister Gunter

Abstract excerpt

Small interfering RNAs (siRNAs) and microRNAs (miRNAs) guide catalytic sequence-specific cleavage of fully or nearly fully complementary target mRNAs or control translation and/or stability of many mRNAs that share 6-8 nucleotides (nt) of complementarity to the siRNA and miRNA 5' end. siRNA- and...

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Identifiers

PMID: 18094121
DOI: 10.1261/rna.789808
PMCID: PMC2212253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18094121-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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