Article
Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression.
Neuron - 1 Nov 1999
Berglund E O, Murai K K, Fredette B, Sekerková G, Marturano B, Weber L, Mugnaini E, Ranscht B
Abstract excerpt
Axon guidance and target recognition depend on neuronal cell surface receptors that recognize and elicit selective growth cone responses to guidance cues in the environment. Contactin, a cell adhesion/recognition molecule of the immunoglobulin gene superfamily, regulates axon growth and fasciculation in vitro, but its role in vivo is unknown. To assess its function in the developing nervous system, we have...
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