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Article

A comparative study of metabolic engineering anti-metabolite tolerance in Escherichia coli.

Metabolic engineering - 1 May 2006

Bonomo Jeanne, Warnecke Tanya, Hume Patrick, Marizcurrena Alex, Gill Ryan T

Abstract excerpt

A problem in strain engineering is that mutations that benefit the expression of a phenotype in one environment may impose a cost to biological fitness in a new environment. The overall objective of this study was to improve understanding of this phenomenon within the context of a classic anti-metabolite selection strategy. We have engineered Escherichia coli using three mutagenesis techniques (chemical...

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Identifiers

PMID: 16497527
DOI: 10.1016/j.ymben.2005.12.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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