A consistent region of deletion on 1p36 in meningiomas: identification and relation to malignant progression.

doi:10.1016/s0165-4608(02)00653-2

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Article

A consistent region of deletion on 1p36 in meningiomas: identification and relation to malignant progression.

Cancer genetics and cytogenetics - 15 Jan 2003

Murakami Mamoru, Hashimoto Naoya, Takahashi Yoshinobu, Hosokawa Youhei, Inazawa Johji, Mineura Katsuyoshi

Abstract excerpt

We analyzed the genetic aberrations on chromosome arms 1p, 10q, and 14q, which are thought to be loci that include putative tumor suppressor genes in meningiomas. We initially conducted molecular genetic testing on a total of 72 tumors including 15 atypical and 8 anaplastic meningiomas using double-target fluorescence in situ hybridization. An incidence of deletion of 1p was observed in 16.3% of histologically...

Topics

Adult
Aged
Alleles
Biomarkers, Tumor
Chromosome Deletion
Chromosomes, Human, Pair 1
Disease Progression
Female
Humans
In Situ Hybridization, Fluorescence
Ki-67 Antigen
Loss of Heterozygosity
Male
Meningeal Neoplasms

Source

Open in PubMed

Identifiers

PMID: 12645646
DOI: 10.1016/s0165-4608(02)00653-2

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Meningioma

Microsatellite Repeats

Middle Aged

Neoplasm Proteins