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DNA Methylation Biomarkers for Blood-Based Colorectal Cancer Screening

18 Dec 2007

Abstract excerpt

BACKGROUND: Sensitive, specific blood-based tests are difficult to develop unless steps are taken to maximize performance characteristics at every stage of marker discovery and development. We describe a sieving strategy for identifying high-performing marker assays that detect colorectal cancer (CRC)-specific methylated DNA in plasma. METHODS: We first used restriction enzyme-based discovery methods to identify...

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PMID: 18089654
DOI: 10.1373/clinchem.2007.095992

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