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Article

Neurofibromin as a regulator of melanocyte development and differentiation.

Journal of cell science - 15 Jan 2008

Diwakar Ganesh, Zhang Deming, Jiang Shunlin, Hornyak Thomas J

Abstract excerpt

Patients with the genetic disease type I neurofibromatosis (NF1) exhibit characteristic pigmentary lesions associated with loss of a single allele of NF1, encoding the 260 kDa protein neurofibromin. To understand the basis for these pigmentary problems, the properties of melanocytes haploinsufficient for the murine gene Nf1 were studied using Nf1(+/-) knockout mice. We demonstrate that neurofibromin regulates the...

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Source

Identifiers

PMID: 18089649
DOI: 10.1242/jcs.013912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Neurofibromin as a regulator of melanocyte development and differentiation.PMID 18089649Read ↗

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