Article
NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model.
Pigment cell & melanoma research - 1 Jul 2015
Larribere Lionel, Wu Huizi, Novak Daniel, Galach Marta, Bernhardt Mathias, Orouji Elias, Weina Kasia, Knappe Nathalie, Sachpekidis Christos, Umansky Ludmila, Beckhove Philipp, Umansky Viktor, De Schepper Sofie, Kaufmann Dieter, Ballotti Robert, Bertolotto Corine, Utikal Jochen
Abstract excerpt
Neurofibromatosis type 1 (NF1) is a frequent genetic disease leading to the development of Schwann cell-derived neurofibromas or melanocytic lesions called café-au-lait macules (CALMs). The molecular mechanisms involved in CALMs formation remain largely unknown. In this report, we show for the first time pathophysiological mechanisms of abnormal melanocyte differentiation in a human NF1(+/-) -induced pluripotent...
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