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Article

Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons.

Cell - 8 Sept 1995

Vogel K S, Brannan C I, Jenkins N A, Copeland N G, Parada L F

Abstract excerpt

Mutations at the neurofibromatosis 1 (NF1) locus in humans and mice result in abnormal growth of neural crest-derived cells, including melanocytes and Schwann cells. We have exploited a targeted disruption of the NF1 gene in mice to examine the role of neurofibromin in the acquisition of neurotrophin dependence in embryonic neurons. We show that both neural crest- and placode-derived sensory neurons isolated from...

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Source

Identifiers

PMID: 7671302
DOI: 10.1016/0092-8674(95)90470-0

Genes

NGF
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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