Article
Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons.
Cell - 8 Sept 1995
Vogel K S, Brannan C I, Jenkins N A, Copeland N G, Parada L F
Abstract excerpt
Mutations at the neurofibromatosis 1 (NF1) locus in humans and mice result in abnormal growth of neural crest-derived cells, including melanocytes and Schwann cells. We have exploited a targeted disruption of the NF1 gene in mice to examine the role of neurofibromin in the acquisition of neurotro...
Topics
- Animals
- Axons
- Cell Survival
- Ganglia, Spinal
- Genes, Neurofibromatosis 1
- Mice
- Mice, Inbred Strains
- Mutation
- Nerve Growth Factors
- Neurofibromin 1
- Neurons, Afferent
- Proteins