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Article

Progesterone-mediated regulation of catechol-O-methyl transferase expression in endometrial cancer cells.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Feb 2008

Salih Sana M, Salama Salama A, Jamaluddin Mohammad, Fadl Amin A, Blok Leen J, Burger Curt W, Nagamani Manubai, Al-Hendy Ayman

Abstract excerpt

The effects of estrogen and progesterone on the expression of estrogen-metabolizing enzymes such as catechol-O-methyl transferase (COMT) are not known. COMT converts genotoxic catecholestrogens to anticarcinogenic methoxyestrogens in the endometrium. The aim of this study is to investigate the effect of progesterone on COMT expression in well-differentiated endometrial cancer cells. The wild-type Ishikawa cell...

Read the complete abstract on PubMed

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Share to Adenocarcinoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Enzymologic

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Share to Receptors, Progesterone

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Source

Identifiers

PMID: 18089588
DOI: 10.1177/1933719107310398

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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