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Article

Polymorphisms of catechol-O-methyltransferase in men with renal cell cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2007

Tanaka Yuichiro, Hirata Hiroshi, Chen Zhong, Kikuno Nobuyuki, Kawamoto Ken, Majid Shahana, Tokizane Takashi, Urakami Shinji, Shiina Hiroaki, Nakajima Koichi, Dhir Rajiv, Dahiya Rajvir

Abstract excerpt

The estrogen metabolite, 4-hydroxy-estrogen, has been shown to play a role in malignant transformation of male kidneys. To counteract the effects of this catechol-estrogen, the catechol-O-methyltransferase (COMT) enzyme is capable of neutralizing the genotoxic effects of this compound. A polymorphic variant of COMT has been shown to have a reduced enzyme activity, and thus, we hypothesize that single nucleotide...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17220335
DOI: 10.1158/1055-9965.EPI-06-0605

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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