Article
IL-12Bpro and GSTP1 polymorphisms in association with silicosis.
Tissue antigens - 1 Feb 2008
Stanilova S, Miteva L, Prakova G
Abstract excerpt
To assess the role of IL-12Bpro and GSTP1 polymorphisms on induced interleukin (IL)-12p40 production in respect to silicosis development, we examined their distribution in 63 silicosis patients and 165 healthy donors. Decreased frequencies of IL-12Bpro-2 allele (42% vs 62.5%, P = 0.0042) and genotype 22 (19% vs 40%, P = 0.02) in patients compared with exposed healthy donors suggested their protective role in...
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