Article
Haplotype analysis of the IGF2-INS-TH gene cluster in Parkinson's disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2008
Sutherland Greg, Mellick George, Newman Jeremy, Double Kay L, Stevens Julia, Lee Linda, Rowe Dominic, Silburn Peter, Halliday Glenda M
Abstract excerpt
Idiopathic Parkinson's disease is a common movement disorder characterized by a loss of dopaminergic neurons in the substantia nigra. Its pathogenesis is postulated to involve complex interactions between genetic susceptibility and environmental exposures. The IGF2-INS-TH gene cluster on the telomeric end of human chromosome 11 is a gene rich region expressing several proteins important for dopamine neuron...
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