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Article

Importance of UDP-glucuronosyltransferase 1A1*6 for irinotecan toxicities in Japanese cancer patients.

Cancer letters - 18 Mar 2008

Sai Kimie, Saito Yoshiro, Sakamoto Hiromi, Shirao Kuniaki, Kurose Koichi, Saeki Mayumi, Ozawa Shogo, Kaniwa Nahoko, Hirohashi Setsuo, Saijo Nagahiro, Sawada Jun-ichi, Yoshida Teruhiko

Abstract excerpt

Recent pharmacogenetic studies on irinotecan have revealed the impact of UDP glucuronosyltransferase (UGT) 1A1*28 on severe irinotecan toxicities. Although the clinical role of UGT1A1*6, which is specifically detected in East Asian patients, in irinotecan toxicities is suggested, clear evidence remains limited. To examine the impact of *6, the association of UGT1A1 genotypes with severe irinotecan toxicities was...

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Identifiers

PMID: 18082937
DOI: 10.1016/j.canlet.2007.11.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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