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Article

UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients.

International journal of clinical oncology - 1 Apr 2009

Onoue Masahide, Terada Tomohiro, Kobayashi Masahiko, Katsura Toshiya, Matsumoto Shigemi, Yanagihara Kazuhiro, Nishimura Takafumi, Kanai Masashi, Teramukai Satoshi, Shimizu Akira, Fukushima Masanori, Inui Ken-ichi

Abstract excerpt

BACKGROUND: Gene polymorphisms of the UDP-glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) contribute to individual variations in adverse events among patients administered irinotecan, and the distribution of the polymorphisms shows large interethnic differences. Variation in the solute...

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Identifiers

PMID: 19390945
DOI: 10.1007/s10147-008-0821-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19390945-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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UGT1A1*6 polymorphism is most predictive of severe neutropenia induced by irinotecan in Japanese cancer patients.PMID 19390945Read ↗

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Association of UGT1A1*6,*28 or ABCC2 c.3972C>T genetic polymorphisms with irinotecan induced toxicity in Asian cancer patients: Meta-analysisSemantic proximity Read ↗

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