Clinical significance of UDP-glucuronosyltransferase 1A1*6 for toxicities of combination chemotherapy with irinotecan and cisplatin in gynecologic cancers: a prospective multi-institutional study.

doi:10.1159/000209335

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Article

Clinical significance of UDP-glucuronosyltransferase 1A1*6 for toxicities of combination chemotherapy with irinotecan and cisplatin in gynecologic cancers: a prospective multi-institutional study.

Oncology - 1 Jan 2009

Takano Masashi, Kato Masafumi, Yoshikawa Tomoyuki, Sasaki Naoki, Hirata Junko, Furuya Kenichi, Takahashi Michiko, Yokota Harushige, Kino Nao, Horie Koji, Goto Tomoko, Fujiwara Keiichi, Ishii Kenji, Kikuchi Yoshihiro, Kita Tsunekazu

Abstract excerpt

BACKGROUND: To investigate the effects of UDP-glucuronosyltransferase 1A1 (UGT1A1) *28, *6 and *27 in patients with gynecologic cancer who received chemotherapy with irinotecan and cisplatin. METHODS: Patients eligible for this study had cervical or ovarian cancer treated with chemotherapy; a course of the regimen consisted of 60 mg/m(2) of irinotecan on days 1, 8 and 15, and 60 mg/m(2) of cisplatin on day 1...

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PMID: 19299905
DOI: 10.1159/000209335

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