Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two Nuclear Localization Signals in USP1 Mediate Nuclear Import of the USP1/UAF1 Complex

6 Jun 2012

Abstract excerpt

The human deubiquitinase USP1 plays important roles in cancer-related processes, such as the DNA damage response, and the maintenance of the undifferentiated state of osteosarcoma cells. USP1 deubiquitinase activity is critically regulated by its interaction with the WD40 repeat-containing protein UAF1. Inhibiting the function of the USP1/UAF1 complex sensitizes cancer cells to chemotherapy, suggesting that this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Genetics and Neurodevelopmental Disorders
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22701671
DOI: 10.1371/journal.pone.0038570

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two Nuclear Localization Signals in USP1 Mediate Nuclear Import of the USP1/UAF1 ComplexPMID 22701671Read ↗

USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy.Semantic proximity Read ↗

USP5: Comprehensive insights into structure, function, biological and disease-related implications, and emerging therapeutic opportunitiesSemantic proximity Read ↗

Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity.Semantic proximity Read ↗

The role of USP1 deubiquitinase in the pathogenesis and therapy of cancerSemantic proximity Read ↗

Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage.Semantic proximity Read ↗

E1-Mediated Recruitment of a UAF1-USP Deubiquitinase Complex Facilitates Human Papillomavirus DNA ReplicationSemantic proximity Read ↗

The deubiquitinating enzyme USP1 modulates ERα and modulates breast cancer progressionSemantic proximity Read ↗

Structural and Functional Investigations of the N-Terminal Ubiquitin Binding Region of Usp25.Semantic proximity Read ↗

A complex of mammalian Ufd1 and Npl4 links the AAA‐ATPase, p97, to ubiquitin and nuclear transport pathwaysSemantic proximity Read ↗

EBNA1-Mediated Recruitment of a Histone H2B Deubiquitylating Complex to the Epstein-Barr Virus Latent Origin of DNA ReplicationSemantic proximity Read ↗

The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair.Semantic proximity Read ↗

USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.