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Article

Proteins containing the UBA domain are able to bind to multi-ubiquitin chains.

Nature cell biology - 1 Oct 2001

Wilkinson C R, Seeger M, Hartmann-Petersen R, Stone M, Wallace M, Semple C, Gordon C

Abstract excerpt

The UBA domain is a motif found in a variety of proteins, some of which are associated with the ubiquitin-proteasome system. We describe the isolation of a fission-yeast gene, mud1+, which encodes a UBA domain containing protein that is able to bind multi-ubiquitin chains. We show that the UBA domain is responsible for this activity. Two other proteins containing this motif, the fission-yeast homologues of Rad23...

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Identifiers

PMID: 11584278
DOI: 10.1038/ncb1001-939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Proteins containing the UBA domain are able to bind to multi-ubiquitin chains.PMID 11584278Read ↗

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UBA domains mediate protein-protein interactions between two DNA damage-inducible proteins.Semantic proximity Read ↗

A synthetic defect in protein degradation caused by loss of Ufd4 and Rad23.Semantic proximity Read ↗

Genome-wide analysis identifies MYND-domain protein Mub1 as an essential factor for Rpn4 ubiquitylation.Semantic proximity Read ↗

Mutations in the 'Fingers' subdomain of the deubiquitinase USP1 modulate its function and activity.Semantic proximity Read ↗

Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast.Semantic proximity Read ↗

Ubiquitin-like proteins and Rpn10 play cooperative roles in ubiquitin-dependent proteolysis.Semantic proximity Read ↗

A proteolytic pathway that recognizes ubiquitin as a degradation signal.Semantic proximity Read ↗

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Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites.Semantic proximity Read ↗

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