Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease.

PloS one - 1 Jan 2014

Wilke Scott A, Raam Tara, Antonios Joseph K, Bushong Eric A, Koo Edward H, Ellisman Mark H, Ghosh Anirvan

Abstract excerpt

The earliest stages of Alzheimer's disease (AD) are characterized by deficits in memory and cognition indicating hippocampal pathology. While it is now recognized that synapse dysfunction precedes the hallmark pathological findings of AD, it is unclear if specific hippocampal synapses are particularly vulnerable. Since the mossy fiber (MF) synapse between dentate gyrus (DG) and CA3 regions underlies critical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Dendritic Spines

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Mutation

Share to Synapses

Source

Open in PubMed Open full text

Identifiers

PMID: 24454724
DOI: 10.1371/journal.pone.0084349
PMCID: PMC3890281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease.PMID 24454724Read ↗

Impaired short-term plasticity in mossy fiber synapses caused by mitochondrial dysfunction of dentate granule cells is the earliest synaptic deficit in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Genetic context drives age-related disparities in synaptic maintenance and structure across cortical and hippocampal neuronal circuitsSemantic proximity Read ↗

Pathway-specific alteration of synaptic plasticity in Tg2576 mice.Semantic proximity Read ↗

Intraneuronal APP and extracellular Aβ independently cause dendritic spine pathology in transgenic mouse models of Alzheimer's disease.Semantic proximity Read ↗

Amyloid deposits show complexity and intimate spatial relationship with dendrosomatic plasma membranes: an electron microscopic 3D reconstruction analysis in 3xTg-AD mice and aged canines.Semantic proximity Read ↗

Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Electron Microscopy Analysis of hAPP-Induced Neurodegeneration in the Glomerular NetworkSemantic proximity Read ↗

Abnormal medial prefrontal cortex connectivity and defective fear extinction in the presymptomatic G93A SOD1 mouse model of ALS.Semantic proximity Read ↗

Spine pruning in 5xFAD mice starts on basal dendrites of layer 5 pyramidal neurons.Semantic proximity Read ↗

Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice.Semantic proximity Read ↗

Synaptopodin regulates denervation-induced plasticity at hippocampal mossy fiber synapsesSemantic proximity Read ↗

Altered synaptic plasticity in the mossy fibre pathway of transgenic mice expressing mutant amyloid precursor protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.