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Article

Excess single-stranded DNA inhibits meiotic double-strand break repair.

PLoS genetics - 1 Nov 2007

Johnson Rebecca, Borde Valérie, Neale Matthew J, Bishop-Bailey Anna, North Matthew, Harris Sheila, Nicolas Alain, Goldman Alastair S H

Abstract excerpt

During meiosis, self-inflicted DNA double-strand breaks (DSBs) are created by the protein Spo11 and repaired by homologous recombination leading to gene conversions and crossovers. Crossover formation is vital for the segregation of homologous chromosomes during the first meiotic division and requires the RecA orthologue, Dmc1. We analyzed repair during meiosis of site-specific DSBs created by another nuclease,...

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Source

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Identifiers

PMID: 18081428
DOI: 10.1371/journal.pgen.0030223
PMCID: PMC2098809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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