Article
A germ line mutation that delays prostate cancer progression and prolongs survival in a murine prostate cancer model.
Oncogene - 7 Jul 2005
Majeed Noreen, Blouin Marie-José, Kaplan-Lefko Paula J, Barry-Shaw Jane, Greenberg Norman M, Gaudreau Pierrette, Bismar Tarek A, Pollak Michael
Abstract excerpt
Circulating insulin-like growth factor-I (IGF-I) levels have been shown to be related to risk of prostate cancer in epidemiologic studies. While specific genetic loci responsible for interindividual variation in circulating IGF-I levels in normal men have not been identified, candidate genes include those involved in the growth hormone (GH)-IGF-I axis such as the hypothalamic factors GH releasing hormone (GHRH)...
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