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The growth hormone-deficient Spontaneous Dwarf rat is resistant to chemically induced mammary carcinogenesis

1 Jun 2002

Abstract excerpt

Recent epidemiologic studies have suggested that the growth hormone (GH)/insulin-like growth factor I axis plays an important role in human breast cancer. The purpose of the present study was to evaluate the function of GH in rat mammary carcinogenesis, a model that closely recapitulates human breast cancer biology. The Spontaneous Dwarf rat (SDR) arose from the Sprague-Dawley rat and harbors a mutation in its GH...

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PMID: 12082019
DOI: 10.1093/carcin/23.6.977

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