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Article

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

The Journal of biological chemistry - 21 Mar 2008

Giorgini Flaviano, Möller Thomas, Kwan Wanda, Zwilling Daniel, Wacker Jennifer L, Hong Soyon, Tsai Li-Chun L, Cheah Christine S, Schwarcz Robert, Guidetti Paolo, Muchowski Paul J

Abstract excerpt

The kynurenine pathway of tryptophan degradation is hypothesized to play an important role in Huntington disease, a neurodegenerative disorder caused by a polyglutamine expansion in the protein huntingtin. Neurotoxic metabolites of the kynurenine pathway, generated in microglia and macrophages, are present at increased levels in the brains of patients and mouse models during early stages of disease, but the...

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PMID: 18079112
DOI: 10.1074/jbc.M708192200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.PMID 18079112Read ↗

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