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Article

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

The Journal of biological chemistry - 21 Mar 2008

Giorgini Flaviano, Möller Thomas, Kwan Wanda, Zwilling Daniel, Wacker Jennifer L, Hong Soyon, Tsai Li-Chun L, Cheah Christine S, Schwarcz Robert, Guidetti Paolo, Muchowski Paul J

Abstract excerpt

The kynurenine pathway of tryptophan degradation is hypothesized to play an important role in Huntington disease, a neurodegenerative disorder caused by a polyglutamine expansion in the protein huntingtin. Neurotoxic metabolites of the kynurenine pathway, generated in microglia and macrophages, a...

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Identifiers

PMID: 18079112
DOI: 10.1074/jbc.M708192200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18079112-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.PMID 18079112Read ↗

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