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Article

Disassociation of histone deacetylase-3 from normal huntingtin underlies mutant huntingtin neurotoxicity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Jul 2013

Bardai Farah H, Verma Pragya, Smith Chad, Rawat Varun, Wang Lulu, D'Mello Santosh R

Abstract excerpt

Huntington's disease (HD) is caused by a polyglutamine expansion within the huntingtin (Htt) protein. Both loss of function of normal Htt and gain of a toxic function by the polyglutamine-expanded mutant Htt protein have been proposed to be responsible for HD, although the molecular mechanisms in...

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Source

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Identifiers

PMID: 23864673
DOI: 10.1523/JNEUROSCI.5831-12.2013
PMCID: PMC3713725

Genes

HDAC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23864673-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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