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Article

Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development.

PLoS genetics - 1 Aug 2017

He Hua, Huang Meina, Sun Shenfei, Wu Yihui, Lin Xinhua

Abstract excerpt

The tree-like structure of the mammalian lung is generated from branching morphogenesis, a reiterative process that is precisely regulated by numerous factors. How the cell surface and extra cellular matrix (ECM) molecules regulate this process is still poorly understood. Herein, we show that epithelial deletion of Heparan Sulfate (HS) synthetase Ext1 resulted in expanded branching tips and reduced branching...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28859094
DOI: 10.1371/journal.pgen.1006992
PMCID: PMC5597256

Genes

SHH

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