Article
Prion strain discrimination in cell culture: the cell panel assay.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2007
Mahal Sukhvir P, Baker Christopher A, Demczyk Cheryl A, Smith Emery W, Julius Christian, Weissmann Charles
Abstract excerpt
Prions are thought to consist mainly or entirely of misfolded PrP, a constitutively expressed host protein. Prions associated with the same PrP sequence may occur in the form of different strains; the strain phenotype is believed to be encoded by the conformation of the PrP. Some cell lines can be persistently infected by prions and, interestingly, show preference for certain strains. We report that a cloned...
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