Article
Demonstration of scrapie strain diversity in infected PC12 cells.
The Journal of general virology - 1 Nov 1992
Rubenstein R, Deng H, Race R E, Ju W, Scalici C L, Papini M C, Kascsak R J, Carp R I
Abstract excerpt
Scrapie strain replication in the nerve growth factor-induced, differentiated PC12 cell culture system was examined. Differences in replication between mouse-derived agents were demonstrated, with the 139A scrapie strain yielding 100- to 1000-fold higher levels of infectivity than the ME7 scrapie strain. Replication was not detected in PC12 cells infected with either the hamster-derived 263K or rat-derived 139R...
Topics
- Acetylcholinesterase
- Animals
- Choline O-Acetyltransferase
- Cricetinae
- Genetic Variation
- Models, Biological
- Nerve Tissue
- Neurotransmitter Agents
- PC12 Cells
- Rats
- Scrapie