Article
Scrapie strains maintain biological phenotypes on propagation in a cell line in culture.
The EMBO journal - 2 Jul 2001
Birkett C R, Hennion R M, Bembridge D A, Clarke M C, Chree A, Bruce M E, Bostock C J
Abstract excerpt
Bovine spongiform encephalopathy (BSE) and its human equivalent, variant Creutzfeldt-Jakob disease (vCJD), are caused by the same strain of infectious agent, which is similar to, but distinct from, >20 strains of their sheep scrapie homologue. A better understanding of the molecular strain determinants could be obtained from cells in monoculture than from whole animal studies where different cell targeting is...
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