Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutability of prions.

EMBO reports - 1 Dec 2011

Li Jiali, Mahal Sukhvir P, Demczyk Cheryl A, Weissmann Charles

Abstract excerpt

Murine prions transferred from brain to cultured cells gradually adapt to the new environment. Brain-derived 22L prions can infect neuroblastoma-derived PK1 cells in the presence of swainsonine (swa); that is, they are 'swa resistant'. PK1 cell-adapted 22L prions are swa sensitive; however, propagation in swa results in selection of swa-resistant substrains. Cloned, PK1 cell-adapted 22L prions were initially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Cell Line
Share to Clone Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance

Share to Mice, Inbred C57BL

Share to Models, Biological

Share to Prions

Source

Open in PubMed Open full text

Identifiers

PMID: 21997293
DOI: 10.1038/embor.2011.191
PMCID: PMC3245691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutability of prions.PMID 21997293Read ↗

Transfer of a prion strain to different hosts leads to emergence of strain variants.Semantic proximity Read ↗

In vitro replication highlights the mutability of prions.Semantic proximity Read ↗

Darwinian evolution of prions in cell culture.Semantic proximity Read ↗

Evidence for preexisting prion substrain diversity in a biologically cloned prion strain.Semantic proximity Read ↗

Heterogeneous seeding of HET-s(218-289) and the mutability of prion structures.Semantic proximity Read ↗

D178N prion protein mutation endows RML prions with new strain properties that do not mimic human genetic prion diseases.Semantic proximity Read ↗

Prion strains: shining new light on old concepts.Semantic proximity Read ↗

Prion strain-dependent differences in conversion of mutant prion proteins in cell culture.Semantic proximity Read ↗

Host Determinants of Prion Strain Diversity Independent of Prion Protein Genotype.Semantic proximity Read ↗

Prion replication environment defines the fate of prion strain adaptation.Semantic proximity Read ↗

Prions on the move.Semantic proximity Read ↗

Changes in prion replication environment cause prion strain mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.