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Article

Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3.

Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2007

Ma Zhendong, Gong Yimei, Patel Vishal, Karner Courtney M, Fischer Evelyne, Hiesberger Thomas, Carroll Thomas J, Pontoglio Marco, Igarashi Peter

Abstract excerpt

Hepatocyte nuclear factor-1beta (HNF-1beta) is a Pit-1, Oct-1/2, Unc-86 (POU) homeodomain-containing transcription factor expressed in the kidney, liver, pancreas, and other epithelial organs. Mutations of HNF-1beta cause maturity-onset diabetes of the young, type 5 (MODY5), which is characterized by early-onset diabetes mellitus and congenital malformations of the kidney, pancreas, and genital tract. Knockout of...

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Share to Chromatin Immunoprecipitation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Suppressor of Cytokine Signaling 3 Protein

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Source

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Identifiers

PMID: 18077349
DOI: 10.1073/pnas.0705957104
PMCID: PMC2154440

Genes

SOCS3
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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