Article
Regulation of a transcription factor network required for differentiation and metabolism.
Science (New York, N.Y.) - 31 Jul 1998
Duncan S A, Navas M A, Dufort D, Rossant J, Stoffel M
Abstract excerpt
Hepatocyte nuclear factors (HNFs) are a heterogeneous class of evolutionarily conserved transcription factors that are required for cellular differentiation and metabolism. Mutations in HNF-1alphaand HNF-4alpha genes impair insulin secretion and cause type 2 diabetes. Regulation of HNF-4/HNF-1 ex...
Topics
- Animals
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Cell Differentiation
- Clone Cells
- DNA-Binding Proteins
- Diabetes Mellitus, Type 2
- Embryonic and Fetal Development
- Endoderm
- Gene Expression Regulation
- Gene Expression Regulation, Developmental
- Gene Targeting
- Glucose
- Hepatocyte Nuclear Factor 1
- Hepatocyte Nuclear Factor 1-alpha
- Hepatocyte Nuclear Factor 1-beta
- Hepatocyte Nuclear Factor 3-alpha
- Hepatocyte Nuclear Factor 3-beta
- Hepatocyte Nuclear Factor 4