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Article

Regulation of a transcription factor network required for differentiation and metabolism.

Science (New York, N.Y.) - 31 Jul 1998

Duncan S A, Navas M A, Dufort D, Rossant J, Stoffel M

Abstract excerpt

Hepatocyte nuclear factors (HNFs) are a heterogeneous class of evolutionarily conserved transcription factors that are required for cellular differentiation and metabolism. Mutations in HNF-1alphaand HNF-4alpha genes impair insulin secretion and cause type 2 diabetes. Regulation of HNF-4/HNF-1 expression by HNF-3alpha and HNF-3beta was studied in embryoid bodies in which one or both HNF-3alpha or HNF-3beta...

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Source

Identifiers

PMID: 9685261
DOI: 10.1126/science.281.5377.692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of a transcription factor network required for differentiation and metabolism.PMID 9685261Read ↗

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