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Article

Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm.

Human genetics - 1 Jan 2002

Ito Teruhiko, Yasue Hirofumi, Yoshimura Michihiro, Nakamura Shota, Nakayama Masafumi, Shimasaki Yukio, Harada Eisaku, Mizuno Yuji, Kawano Hiroaki, Ogawa Hisao

Abstract excerpt

We recently reported that oxidative stress is involved in the pathogenesis of coronary spasm. We hypothesized that oxidative-stress-related genetic factors and certain polymorphisms in the paraoxonase gene (PON1) and platelet-activating factor acetylhydrolase (PAF-AH) might influence the pathogenesis of coronary spasm. We therefore examined the possible association between the PON1 Q192R or PAF-AH V279F...

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Source

Identifiers

PMID: 11810302
DOI: 10.1007/s00439-001-0654-6

Genes

PON1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm.PMID 11810302Read ↗

Genetic risk and gene-environment interaction in coronary artery spasm in Japanese men and women.Semantic proximity Read ↗

First survey of the three gene polymorphisms (PON1 Q192R, eNOS E298D and eNOS C-786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data.Semantic proximity Read ↗

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Association of endothelial nitric oxide synthase (Glu298Asp) gene polymorphism with radial artery spasm during cardiac catheterization in Egyptians.Semantic proximity Read ↗

Paraoxonase 1 L55M, Q192R and paraoxonase 2 S311C alleles in atherothrombosis.Semantic proximity Read ↗

A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese.Semantic proximity Read ↗

Paraoxonase polymorphism (Gln192Arg) as a determinant of the response of human coronary arteries to serotonin.Semantic proximity Read ↗

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A novel genetic marker for coronary spasm in women from a genome-wide single nucleotide polymorphism analysis.Semantic proximity Read ↗

Impact of paraoxonase polymorphism (Q192R) on endothelial function in intact coronary circulation.Semantic proximity Read ↗

The Glu298Asp polymorphism in the endothelial nitric oxide synthase gene is strongly associated with coronary spasm.Semantic proximity Read ↗

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