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Article

Protein evolution by hypermutation and selection in the B cell line DT40

13 Nov 2007

Abstract excerpt

Genome-wide mutations and selection within a population are the basis of natural evolution. A similar process occurs during antibody affinity maturation when immunoglobulin genes are hypermutated and only those B cells which express antibodies of improved antigen-binding specificity are expanded. Protein evolution might be simulated in cell culture, if transgene-specific hypermutation can be combined with the...

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PMID: 18073192
DOI: 10.1093/nar/gkm616

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