Article

Brønsted-basic small molecules activate GTP hydrolysis in Ras Q61 mutants

2025-11-06

Abstract excerpt

The RAS oncogenes ( KRAS , HRAS , NRAS ) are among the most frequently mutated genes in human cancer, affecting over three million patients annually. Therapeutic development has largely focused on inhibitors for KRAS codon 12 mutations (G12C/D/V/S/R) which are key drivers in lung, colorectal, and pancreatic cancers. In contrast, mutant-selective inhibitors for Q61 variants remain elusive. A common mechanistic...

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Literature Corpus work: 52418ffb-05b2-54c0-a69b-fd26266c20e9
DOI: 10.1101/2025.11.04.686643

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