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Article

Are all the DNA gyrase mutations found in Mycobacterium leprae clinical strains involved in resistance to fluoroquinolones?

Antimicrobial agents and chemotherapy - 1 Feb 2008

Matrat Stéphanie, Cambau Emmanuelle, Jarlier Vincent, Aubry Alexandra

Abstract excerpt

Mycobacterium leprae DNA gyrases carrying various mutations, previously described in clinical strains, were investigated for quinolone susceptibility by inhibition of supercoiling and DNA cleavage promotion. We demonstrated that the gyrA mutations leading to G89C or A91V confer fluoroquinolone resistance whereas the gyrB mutation leading to D205N does not.

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Identifiers

PMID: 18070975
DOI: 10.1128/AAC.01095-07
PMCID: PMC2224767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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