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In Vitro-Selected Linezolid-Resistant <i>Mycobacterium tuberculosis</i> Mutants

11 Dec 2007

Abstract excerpt

Development of resistance against linezolid, an alternative drug for the therapy of multidrug-resistant tuberculosis (2), was assessed to be rare (5). We aimed to generate linezolid-resistant Mycobacterium tuberculosis strains from 10 different, fully susceptible M. tuberculosis parental strains. Ten linezolid-resistant colonies could be isolated from six different parental strains. The frequency of the in vitro...

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PMID: 18070973
DOI: 10.1128/aac.01189-07

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