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Article

Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS.

Molecular and cellular biology - 1 Feb 2008

Yamashita Toshiharu, Ohneda Osamu, Nagano Masumi, Iemitsu Motoyuki, Makino Yuichi, Tanaka Hirotoshi, Miyauchi Takashi, Goto Katsutoshi, Ohneda Kinuko, Fujii-Kuriyama Yoshiaki, Poellinger Lorenz, Yamamoto Masayuki

Abstract excerpt

Hypoxia-inducible factors (HIFs) are crucial for oxygen homeostasis during both embryonic development and postnatal life. Here we show that a novel HIF family basic helix-loop-helix (bHLH) PAS (Per-Arnt-Sim) protein, which is expressed predominantly during embryonic and neonatal stages and thereby designated NEPAS (neonatal and embryonic PAS), acts as a negative regulator of HIF-mediated gene expression. NEPAS...

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Identifiers

PMID: 18070924
DOI: 10.1128/MCB.01332-07
PMCID: PMC2258751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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