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Article

Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain.

The Journal of biological chemistry - 29 Oct 1999

Maemura K, Hsieh C M, Jain M K, Fukumoto S, Layne M D, Liu Y, Kourembanas S, Yet S F, Perrella M A, Lee M E

Abstract excerpt

Endothelial PAS domain protein 1 (EPAS1) is a basic helix-loop-helix/PAS domain transcription factor that is preferentially expressed in vascular endothelial cells. EPAS1 shares high homology with hypoxia-inducible factor-1alpha (HIF-1alpha) and, like HIF-1alpha, has been shown to bind to the HIF-1-binding site and to activate its downstream genes such as vascular endothelial growth factor (VEGF) and...

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Source

Identifiers

PMID: 10531360
DOI: 10.1074/jbc.274.44.31565

Genes

EPAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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