Article
Generation of a dominant-negative mutant of endothelial PAS domain protein 1 by deletion of a potent C-terminal transactivation domain.
The Journal of biological chemistry - 29 Oct 1999
Maemura K, Hsieh C M, Jain M K, Fukumoto S, Layne M D, Liu Y, Kourembanas S, Yet S F, Perrella M A, Lee M E
Abstract excerpt
Endothelial PAS domain protein 1 (EPAS1) is a basic helix-loop-helix/PAS domain transcription factor that is preferentially expressed in vascular endothelial cells. EPAS1 shares high homology with hypoxia-inducible factor-1alpha (HIF-1alpha) and, like HIF-1alpha, has been shown to bind to the HIF-1-binding site and to activate its downstream genes such as vascular endothelial growth factor (VEGF) and...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Cattle
- DNA-Binding Proteins
- Deferoxamine
- Endothelial Growth Factors
- Endothelium, Vascular
- Fungal Proteins
- Hypoxia-Inducible Factor 1
- Hypoxia-Inducible Factor 1, alpha Subunit