Article
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development.
Genes & development - 1 Nov 1998
Tian H, Hammer R E, Matsumoto A M, Russell D W, McKnight S L
Abstract excerpt
Mice lacking the hypoxia-inducible transcription factor EPAS1 die at mid-gestation. Despite normal morphological development of the circulatory system, EPAS1-deficient mice display pronounced bradycardia. In addition to the vascular endothelium, EPAS1 is expressed intensively in the organ of Zuck...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Catecholamines
- Embryonic and Fetal Development
- Heart Failure
- Helix-Loop-Helix Motifs
- Homeostasis
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Phenotype
- Trans-Activators