Article
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: non-symmetric inhibitors with potent activity against genotype 1a and 1b.
Bioorganic & medicinal chemistry letters - 15 Feb 2015
Giroux Simon, Bilimoria Darius, Cadilhac Caroline, Cottrell Kevin M, Denis Francois, Dietrich Evelyne, Ewing Nigel, Henderson James A, L'Heureux Lucille, Mani Nagraj, Morris Mark, Nicolas Olivier, Reddy T Jagadeeswar, Selliah Subajini, Shawgo Rebecca S, Xu Jinwang, Chauret Nathalie, Berlioz-Seux Francoise, Chan Laval C, Das Sanjoy K, Grillot Anne-Laure, Bennani Youssef L, Maxwell John P
Abstract excerpt
The discovery of non-symmetric thienoimidazole-containing HCV NS5A inhibitors is described. The inhibitors herein reported display high potencies against both genotype 1a and 1b. In this follow-up manuscript, we discuss the importance of the linker aromaticity to achieve high potency, particularly against genotype 1a.
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