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Article

Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling.

Nature neuroscience - 1 Jan 2008

Li Xiaoling, Gao Xue, Liu Guofa, Xiong Wencheng, Wu Jane, Rao Yi

Abstract excerpt

Netrins are prototypical axon guidance cues whose attractive signaling requires the small GTPase Rac1. It remains unclear how Rac1 is regulated in the netrin pathway. DOCK180 is a member of a new family of guanine nucleotide exchange factors for Rho GTPases. Here we provide evidence implicating DOCK180 in netrin signal transduction. Netrin promoted the formation of a protein-protein interaction complex that...

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Identifiers

PMID: 18066058
DOI: 10.1038/nn2022
PMCID: PMC2262939

Genes

DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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