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Article

Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline.

Neuron - 25 Sept 2003

Fan Xueping, Labrador Juan Pablo, Hing Huey, Bashaw Greg J

Abstract excerpt

Drosophila Roundabout (Robo) is the founding member of a conserved family of repulsive axon guidance receptors that respond to secreted Slit proteins. Here we present evidence that the SH3-SH2 adaptor protein Dreadlocks (Dock), the p21-activated serine-threonine kinase (Pak), and the Rac1/Rac2/Mt...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14527437
DOI: 10.1016/s0896-6273(03)00591-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14527437-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline.PMID 14527437Read ↗

Chimeric axon guidance receptors: the cytoplasmic domains of slit and netrin receptors specify attraction versus repulsion.Semantic proximity Read ↗

Short-range and long-range guidance by slit and its Robo receptors. Robo and Robo2 play distinct roles in midline guidance.Semantic proximity Read ↗

Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor.Semantic proximity Read ↗

Slit is the midline repellent for the robo receptor in Drosophila.Semantic proximity Read ↗

RETRACTED: Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex.Semantic proximity Read ↗

Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.Semantic proximity Read ↗

Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling.Semantic proximity Read ↗

Slit/Robo-mediated axon guidance in Tribolium and Drosophila: divergent genetic programs build insect nervous systems.Semantic proximity Read ↗

Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline.Semantic proximity Read ↗

Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons.Semantic proximity Read ↗

Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein.Semantic proximity Read ↗

Switching repulsion to attraction: changing responses to slit during transition in mesoderm migration.Semantic proximity Read ↗

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