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Article

Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase

2 Jun 2020

Abstract excerpt

Telomeres cap the ends of eukaryotic chromosomes and distinguish them from broken DNA ends to suppress DNA damage response, cell cycle arrest and genomic instability. Telomeres are elongated by telomerase to compensate for incomplete replication and nuclease degradation and to extend the proliferation potential of germ and stem cells and most cancers. However, telomeres in somatic cells gradually shorten with...

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Share to Chromosomal and Genetic Variations
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PMID: 32542379
DOI: 10.1093/nar/gkaa503

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