Article
Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice.
Genesis (New York, N.Y. : 2000) - 1 Jul 2006
Li Jia, Chen Ken, Zhu Liyin, Pollard Jeffrey W
Abstract excerpt
Colony stimulating factor-1 (CSF-1) is the primary regulator of the mononuclear phagocytic lineage acting through its transmembrane tyrosine kinase receptor, CSF-1R, that is the product of the c-fms proto-oncogene. Null mutations in either the ligand or the receptor genes result in a severe osteopetrosis as well as a number of other phenotypes, including reproductive defects and perturbations in organ...
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