Article
Immunoglobulin diversity gene usage predicts unfavorable outcome in a subset of chronic lymphocytic leukemia patients.
The Journal of clinical investigation - 1 Jan 2008
Tschumper Renee C, Geyer Susan M, Campbell Megan E, Kay Neil E, Shanafelt Tait D, Zent Clive S, Nowakowski Grzegorz S, Call Timothy G, Dewald Gordon W, Jelinek Diane F
Abstract excerpt
Survival of patients with B cell chronic lymphocytic leukemia (B-CLL) can be predicted by analysis of mutations in the immunoglobulin heavy chain variable gene (IGHV). Patients without mutations (unmutated [UM]) are at greater risk for disease progression and death than patients with mutations (M). Despite this broad prognostic difference, there remains wide intragroup variation in the clinical outcome of UM...
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