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Article

Immunoglobulin heavy chain variable region gene repertoire and B-cell receptor stereotypes in Indian patients with chronic lymphocytic leukemia.

Leukemia & lymphoma - 1 Oct 2016

Rani Lata, Mathur Nitin, Gogia Ajay, Vishnubhatla Sreenivas, Kumar Lalit, Sharma Atul, Dube Divya, Kaur Punit, Gupta Ritu

Abstract excerpt

In chronic lymphocytic leukemia (CLL), the geographical bias in immunoglobulin heavy-chain variable (IGHV) gene usage lead us to analyze IGHV gene usage and B-cell receptor stereotypy in 195 patients from India. IGHV3, IGHV4, and IGHV1 families were the most frequently used. 20.5% sequences had stereotyped BCR and were clustered in 12 pre-defined and 6 novel subsets. Unmutated IGHV was significantly associated...

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Share to Complementarity Determining Regions
Share to Gene Rearrangement, B-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin Heavy Chain

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Share to Neoplasm Staging

Share to Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 26942309
DOI: 10.3109/10428194.2016.1153086

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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