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Article

Loss of aromatase cytochrome P450 function as a risk factor for Parkinson's disease?

Brain research reviews - 1 Mar 2008

Morale M C, L'Episcopo F, Tirolo C, Giaquinta G, Caniglia S, Testa N, Arcieri P, Serra P-A, Lupo G, Alberghina M, Harada N, Honda S, Panzica G C, Marchetti Bianca

Abstract excerpt

The final step in the physiological synthesis of 17beta estradiol (E(2)) is aromatization of precursor testosterone by a CYP19 gene product, cytochrome P450 estrogen aromatase in the C19 steroid metabolic pathway. Within the central nervous system (CNS) the presence, distribution, and activity of aromatase have been well characterized. Developmental stage and injury are known modulators of brain enzyme activity,...

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Identifiers

PMID: 18063054
DOI: 10.1016/j.brainresrev.2007.10.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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