Article
Prepulse inhibition of acoustic startle in aromatase knock-out mice: effects of age and gender.
Genes, brain, and behavior - 1 Apr 2003
van den Buuse M, Simpson E R, Jones M E E
Abstract excerpt
Estrogen has been suggested to play a neuromodulatory and neuroprotective role on the brain dopamine system. We used aromatase knockout (ArKO) mice that lack a functional aromatase enzyme and are unable to convert testosterone into estrogen, and assessed prepulse inhibition of acoustic startle, locomotor hyperactivity to amphetamine treatment and rotarod performance. Mice were tested at either 1 month, 4-5 months...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.