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Article

Quercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73.

BMC cancer - 11 Jun 2010

Thangasamy Thilakavathy, Sittadjody Sivanandane, Mitchell Geoffrey C, Mendoza Erin E, Radhakrishnan Vijayababu M, Limesand Kirsten H, Burd Randy

Abstract excerpt

BACKGROUND: The alkylating agent dacarbazine (DTIC) has been used in the treatment of melanoma for decades, but when used as a monotherapy for cancer only moderate response rates are achieved. Recently, the clinical use of temozolomide (TMZ) has become the more commonly used analog of DTIC-related oral agents because of its greater bioavailability and ability to cross the blood brain barrier. The response rates...

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PMID: 20540768
DOI: 10.1186/1471-2407-10-282
PMCID: PMC2895613

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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