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Article

Imiquimod activates p53-dependent apoptosis in a human basal cell carcinoma cell line.

Journal of dermatological science - 1 Mar 2016

Huang Shi-Wei, Chang Shu-Hao, Mu Szu-Wei, Jiang Hsin-Yi, Wang Sin-Ting, Kao Jun-Kai, Huang Jau-Ling, Wu Chun-Ying, Chen Yi-Ju, Shieh Jeng-Jer

Abstract excerpt

BACKGROUND: The tumor suppressor p53 controls DNA repair, cell cycle, apoptosis, autophagy and numerous other cellular processes. Imiquimod (IMQ), a synthetic toll-like receptor (TLR) 7 ligand for the treatment of superficial basal cell carcinoma (BCC), eliminates cancer cells by activating cell-mediated immunity and directly inducing apoptosis and autophagy in cancer cells. OBJECTIVE: To evaluate the role of p53...

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Source

Identifiers

PMID: 26775629
DOI: 10.1016/j.jdermsci.2015.12.011

Genes

ATM
ATR
TLR7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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